The adipocyte in insulin resistance: Key molecules and the impact of the thiazolidinediones

来自 dx.doi.org

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阅读量：

106

作者：

P Arner

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摘要：

Globally, the prevalence of obesity is escalating, and insulin resistance resulting from increased (predominantly visceral) adipose tissue mass has been identified as a key factor that could drive parallel rises in type 2 diabetes mellitus (T2DM) prevalence. Correlations between these global epidemics have encouraged investigation into potential molecular links between the related impairments in lipid and glucose homeostasis. This article reviews factors released from adipose tissue that could contribute to the development of insulin resistance and β-cell dysfunction, including tumour necrosis factor α (TNF-α), free fatty acids (FFAs), adiponectin, resistin and leptin. It also considers whether agonists of the peroxisome proliferator-activated receptor γ, which is abundant in adipose tissue, might have an important impact on factors associated with adipocyte metabolism. For example, the thiazolidinediones, a class of oral anti-diabetic agents that reduce insulin resistance and improve β-cell function, might mediate these effects by regulating adipocyte-derived factors, in particular TNF-α and FFAs.

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关键词：

Insulin Resistance Adipocytes Adipose tissue Prevalence aspects 胰岛素抗药性脂细胞

DOI：

10.1016/S1043-2760(03)00024-9

被引量：

1193

年份：

2003