Akt/Protein Kinase B Inhibits Cell Death by Preventing the Release of Cytochrome c from Mitochondria
摘要：
Growth factors signaling through the 3-kinase/pathway promote cell survival. The mechanism by which the serine/threonine kinase prevents remains unclear. We have previously shown that inhibits the activity of DEVD-targeted caspases without changing the steady-state levels of and Bcl-x(L). Here we show that inhibits and the processing of procaspases to their active forms by delaying mitochondrial changes in a caspase-independent manner. activation is sufficient to inhibit the release of from mitochondria and the alterations in the inner potential. However, cannot inhibit induced by microinjection of . We also demonstrated that inhibits and release induced by several proapoptotic family members. Taken together, our results show that promotes cell survival by intervening in the cascade before release and via a mechanism that is distinct from Bad .
展开
关键词：
Animals Rats Mitochondria Intracellular Membranes Cytochrome c Group Caspases Proteins Membrane Proteins Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2
DOI：
10.1128/MCB.19.8.5800
被引量：
年份：
1999
万方医学
Semantic Scholar
(全网免费下载)
Europe PMC
NCBI
Oxford Univ Press
查看更多
NCBI
(全网免费下载)
Cell Press
JBC
AACR
ResearchGate
ResearchGate
(全网免费下载)
Citeseer
Citeseer
(全网免费下载)
genesdev.cshlp.org
jlr.org
mcb.asm.org
molbiolcell.org
jimmunol.org
deepdyve.com
mendeley.com
fasebj.org
elifesciences.org
molpharm.aspetjournals.org
ajpcell.physiology.org
bvsalud.org
jleukbio.org
bloodjournal.org
mysciencework.com
core.ac.uk
jasn.asnjournals.org
mcb.asm.org
(全网免费下载)
jem.rupress.org
cghjournal.org
osti.gov
(全网免费下载)
pnas.org
circ.ahajournals.org
Semantic Scholar
(全网免费下载)
NCBI
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
mcb.asm.org
(全网免费下载)
osti.gov
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
