Monoclonal antibodies defining distinctive human T cell surface antigens
摘要：
Three novel monoclonal antibodies (designated OKT1, OKT3, and OKT4) were generated against surface determinants of human peripheral T cells. Both OKT1 and OKT3 reacted with all human peripheral T cells and 5 to 10 percent of thymocytes but differed in their reactivities with T cell lines. By contrast, OKT4 reacted with 55 percent of human peripheral T cells and 80 percent of thymocytes. All three antibodies were selective for T cells in the peripheral blood in that they did not react with normal B cells, null cells, monocytes, or granulocytes.
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关键词：
basic biological sciences antibodies diagnostic uses antigen-antibody reactions comparative evaluations antigens hybridization leukocytes lymphocytes man
DOI：
10.1126/science.314668
被引量：
年份：
1979
Taylor & Francis
Semantic Scholar
万方医学
dx.doi.org
NCBI
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