An Induced Proximity Model for NF-κB Activation in the Nod1/RICK and RIP Signaling Pathways
摘要：
Nod1 is an Apaf-1-like molecule composed of a caspase-recruitment domain (CARD), nucleotide-binding domain, and leucine-rich repeats that associates with the CARD-containing kinase RICK and activates nuclear factor κB (NF-κB). We show that self-association of Nod1 mediates proximity of RICK and the interaction of RICK with the γ subunit of the IκB kinase (IKKγ). Similarly, the RICK-related kinase RIP associated via its intermediate region with IKKγ. A mutant form of IKKγ deficient in binding to IKKα and IKKβ inhibited NF-κB activation induced by RICK or RIP. Enforced oligomerization of RICK or RIP as well as of IKKγ, IKKα, or IKKβ was sufficient for induction of NF-κB activation. Thus, the proximity of RICK, RIP, and IKK complexes may play an important role for NF-κB activation during Nod1 oligomerization or trimerization of the tumor necrosis factor α receptor.
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关键词：
Animals Humans Mice Fibroblasts Cell Line Adaptor Proteins, Signal Transducing Proteins Protein Kinases NF-kappa B Transfection
DOI：
10.1074/jbc.M003415200
被引量：
年份：
2000
Elsevier
BMJ
Semantic Scholar
万方医学
dx.doi.org
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