Predominant Autoantibody Production by Early Human B Cell Precursors
摘要：
During B lymphocyte development, antibodies are assembled by random gene segment reassortment to produce a vast number of specificities. A potential disadvantage of this process is that some of the antibodies produced are self-reactive. We determined the prevalence of self-reactive antibody formation and its regulation in human B cells. A majority (55 to 75%) of all antibodies expressed by early immature B cells displayed self-reactivity, including poly-reactive and anti-nuclear specificities. Most of these autoantibodies were removed from the population at two discrete checkpoints during B cell development. Inefficient checkpoint regulation would lead to substantial increases in circulating autoantibodies.
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关键词：
Humans B-Lymphocytes Cytosol Cell Line Tumor Cells, Cultured Complementarity Determining Regions Autoantibodies Antibodies, Antinuclear Cell Differentiation Antibody Diversity
DOI：
10.1126/science.1086907
被引量：
年份：
2003
BMJ
万方医学
掌桥科研
Europe PMC
Cell Press
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