G1 events and regulation of cell proliferation
摘要：
Cells prepare for S phase during the G$_{1}$ phase of the cell cycle. Cell biological methods have provided knowledge of cycle kinetics and of substages of G$_{1}$ that are determined by extracellular signals. Through the use of biochemical and molecular biological techniques to study effects of growth factors, oncogenes, and inhibitors, intracellular events during G$_{1}$ that lead to DNA synthesis are rapidly being discovered. Many cells in vivo are in a quiescent state (G$_{0}$), with unduplicated DNA. Cells can be activated to reenter the cycle during G$_{1}$ Similarly, cells in culture can be shifted between G$_{0}$ and G$_{1}$. These switches in and out of G$_{1}$ are the main determinants of post-embryonic cell proliferation rate and are defectively controlled in cancer cells.
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关键词：
Animals Humans Cell Membrane Cell Nucleus Signal Transduction Cell Division Interphase Gene Expression Neoplasms Cell Cycle
DOI：
10.1126/science.2683075
被引量：
年份：
1989
Semantic Scholar
万方医学
dx.doi.org
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