Activation of the Cytoplasmic c-Abl Tyrosine Kinase by Reactive Oxygen Species
摘要：
The ubiquitously expressed c-Abl protein tyrosine kinase localizes to both the nucleus and cytoplasm. The nuclear form of c-Abl is activated in the cellular response to genotoxic stress. Here we show that cytoplasmic c-Abl is activated by oxidative stress. The results also demonstrate that mitochondrial cytochrome c is released in the cellular response to H(2)O(2) and that this effect is mediated by a c-Abl-dependent mechanism. In concert with these results, we show that H(2)O(2)-induced apoptosis is attenuated in c-Abl-deficient cells. These findings demonstrate that cytoplasmic c-Abl is involved in the apoptotic response of cells to oxidative stress.
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关键词：
Cells, Cultured COS Cells Cell Nucleus Cytoplasm Fibroblasts Animals Mice, Knockout Mice Hydrogen Peroxide Reactive Oxygen Species
DOI：
10.1074/jbc.C000099200
被引量：
年份：
2000
Elsevier
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Wiley
万方医学
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