Where attention falls: Increased risk of falls from the converging impact of cortical cholinergic and midbrain dopamine loss on striatal function
摘要：
Falls in PD result from dual dopaminergic–cholinergic loss.Cortical cholinergic activity provides attentional control of movement.Cholinergic loss "unmasks" fall risk resulting from striatal dopamine loss.A cortico-striatal circuitry model for falls is discussed.The circuitry model suggests therapeutic efficacy of α4β2* nAChR agonists.
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DOI：
10.1016/j.expneurol.2014.04.032
被引量：
年份：
2014
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