Autophagy Defends Cells Against Invading Group A Streptococcus
摘要：
We found that the autophagic machinery could effectively eliminate pathogenic group A Streptococcus (GAS) within nonphagocytic cells. After escaping from endosomes into the cytoplasm, GAS became enveloped by autophagosome-like compartments and were killed upon fusion of these compartments with lysosomes. In autophagy-deficient$Atg5^{-/-}$cells, GAS survived, multiplied, and were released from the cells. Thus, the autophagic machinery can act as an innate defense system against invading pathogens.
展开
DOI：
10.1126/science.1103966
被引量：
年份：
2004
Semantic Scholar
掌桥科研
万方医学
Semantic Scholar
(全网免费下载)
dx.doi.org
查看更多
Oxford Univ Press
NCBI
NCBI
Europe PMC
JSTOR
Cell Press
JBC
adsabs.harvard.edu
dialnet.unirioja.es
ProQuest
ResearchGate
(全网免费下载)
ResearchGate
EBSCO
Citeseer
(全网免费下载)
go.galegroup.com
molbiolcell.org
osaka-u.ac.jp
(全网免费下载)
140.116.203.51
(全网免费下载)
www.socolar.com
jem.rupress.org
iai.asm.org
sciencemag.org
onAcademic
genesdev.cshlp.org
cancerdiscovery.aacrjournals.org
f1000.com
highbeam.com
jacionline.org
jimmunol.org
deepdyve.com
cghjournal.org
pubfacts.com
fasebj.org
jleukbio.org
pubget.com
emboj.embopress.org
scienceopen.com
d.scholar.cnki.net
mendeley.com
jcs.biologists.org
science-open.com
elifesciences.org
readcube.com
mysciencework.com
g3journal.org
Semantic Scholar
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
140.116.203.51
(全网免费下载)
osaka-u.ac.jp
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
请先登入
相似文献
参考文献
引证文献
辅助模式
0
引用
文献可以批量引用啦~
欢迎点我试用！
