Fluorouracil in colorectal cancer--a tale of two drugs: implications for biochemical modulation.
摘要：
To determine if fluorouracil (FUra) has different mechanisms of action as a function of the dose schedule used.The preclinical and clinical literature relating toxicity and antitumor effects of FUra as a function of its dose schedule, with and without modulating agents, was reviewed.The data support the hypothesis that FUra may be considered to be two different drugs, depending on its dose schedule (bolus v continuous infusion [CI]).These results suggest that additional therapeutic benefit may be obtained from FUra regimens by (1) appropriate schedule-dependent modulation, (2) the sequential or alternating use of cycles of bolus followed by cycles of CI FUra appropriately modulated, or (3) hybrid regimens, ie, those that contain both pulse and CI schedules.
展开
关键词：
Antimetabolites, Antineoplastic Colorectal Neoplasms Fluorouracil Antidotes Dose Response Relationship, Drug Drug Administration Schedule Infusions, Intra Arterial Infusions, Intravenous Leucovorin Methotrexate
DOI：
10.1200/JCO.1997.15.1.368
被引量：
年份：
1997
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
引用走势
站内活动
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
