摘要：

Many of patients are suffering from severe acidity and heart burning and gastro esophagus reflux disease problem which can be overcame by formulating raft forming tablet containing antacid and proton pump inhibitor. The main objective of this research is to formulate and evaluate raft forming tablets of proton pump inhibitor(Esomeprazole magnesium trihydrate) along with raft forming agents sodium alginate and pectin and antacid(NaHCO3). The tablet was prepared by wet granulation method and evaluated for raft strength, acid neutralization capacity, in vitro drug release. The tablet containing appropriate amount of sodium alginate with pectin having highest raft strength. Raft strength was affected by amount of sodium alginate and pectin, and sodium bicarbonate. A 32 full factorial design was used in present study of optimization. Amount of sodium alginate, and amount of sodium bicarbonate was used as an independent variable and raft strength, acid neutralization capacity and Q30 was used as dependent variable. Acid neutralization capacity and in vitro drug release of all batches was found to be satisfactory. F6 batch was optimized on based on maximum raft strength and good neutralization capacity and in vitro drug release within 1 hr. Stability study of optimized formulation showed that tablets were stable at accelerated condition. It can be conclude that raft forming tablet containing esomeprazole magnesium trihydrate could be an efficient dosage form for treatment of heart burning, GERD, erosive esophagitis and peptic ulcer.

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