GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours
摘要：
A subset of growth hormone-secreting human pituitary tumours carries somatic mutations that inhibit GTPase activity of a G protein α chain, αs. The resulting activation of adenylyl cyclase bypasses the cells' normal requirement for trophic hormone. Amino acids substituted in the putative gsp oncogene identify a domain of G protein α-chains required for intrinsic ability to hydrolyse GTP. This domain may serve as a built-in counter-part of the separate GTPase-activating proteins required for GTP hydrolysis by small GTP-binding proteins such as p21ras.
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关键词：
Humans Pituitary Neoplasms GTP Phosphohydrolases GTP-Binding Proteins Adenylate Cyclase Arginine Glutamine Phosphoric Monoester Hydrolases Neoplasm Proteins Proto-Oncogene Proteins
DOI：
10.1038/340692a0
被引量：
年份：
1989
Nature
Nature
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Wiley
Semantic Scholar
万方医学
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