Phosphoinositides as Regulators in Membrane Traffic
摘要：
Phosphorylated products of phosphatidylinositol play critical roles in the regulation of membrane traffic, in addition to their classical roles as second messengers in signal transduction at the cell surface. Growing evidence suggests that phosphorylation-dephosphorylation of the polar heads of phosphoinositides (polyphosphorylated inositol lipids) in specific intracellular locations signals either the recruitment or the activation of proteins essential for vesicular transport. Cross talk between phosphatidylinositol metabolites and guanosine triphosphatases is an important feature of these regulatory mechanisms.
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关键词：
Assembly protein ap 2 Lysosome like vacuole Phosphatidylinositol 3 kinase Kinase Clathrin Binding Receptor Pathway Vps34. Internalization
DOI：
10.1126/science.271.5255.1533
被引量：
年份：
1996
万方医学
掌桥科研
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