Premedication with nasal s-ketamine and midazolam provides good conditions for induction of anesthesia in preschool children.

来自 EBSCO

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摘要：

To evaluate the efficacy and safety of intranasally administered s-ketamine and midazolam for premedication in pediatric patients. Ninety children were randomly allocated to receive intranasally administered s-ketamine 1 mg.kg(-1) and midazolam 0.2 mg.kg(-1) (Group K1, n = 30), s-ketamine 2 mg.kg(-1) and midazolam 0.2 mg.kg(-1) (Group K2, n = 30), or midazolam 0.2 mg.kg(-1) (Group M, n = 30) as premedicants, using a double-blind study design. Sedation and anxiolysis were evaluated using a sedation and cooperation scale and recorded at several time points. Acceptable conditions (K1: 23; K2: 26, M: 19) for parental separation were not different between groups. Induction conditions were acceptable in 26 patients in K2 (P < 0.05 vs M) (K1: 23; M: 19). Compared to baseline values individual conditions significantly improved in groups K1 and K2 from 2.5 min after premedication until induction of anesthesia (P < 0.003), in group M conditions improved only five minutes after premedication (P < 0.05). Adverse effects observed in this series were within an acceptable range and similar for the three groups. Intranasal administration of s-ketamine and midazolam is an appropriate premedication in preschool children.

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关键词：

monitoring, bispectral index monitoring, electroencephalography surgery, paediatric surgery, cardiovascular

DOI：

10.1007/BF03021058

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年份：

2003