Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila.
摘要：
Proteins with expanded polyglutamine repeats cause Huntington's disease and other neurodegenerative diseases. Transcriptional dysregulation and loss of function of transcriptional coactivator proteins have been implicated in the pathogenesis of these diseases
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关键词：
Animals Animals, Genetically Modified Rats Drosophila Huntington Disease Neurodegenerative Diseases Disease Models, Animal Nerve Degeneration Glutamine Peptides
DOI：
10.1038/35099568
被引量：
年份：
2001
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