摘要：

Phosphatidylcholine molecules bearing thiol and disulfide moieties at the terminus of both the sn-1 and sn-2 chains have been synthesized and chemisorbed onto freshly evaporated gold film. A combination of ellipsometry, contact angle measurements, heterogeneous electron-transfer properties, and X-ray photoelectron spectroscopy has shown that 1,2-bis(16-mercaptohexadecanoyl)- sn-glycero-3-phosphocholine and 1,2-bis[12-(lipoyloxy) dodecanoyl]-sn-glycero-3-phosphocholine yield chemisorbed monolayers which are (i) densely packed, (ii) macroscopically uniform, (iii) strongly hydrophilic, and (iv) oriented such that the polar head groups extend outward from the surface and the sulfur moieties are in intimate contact with the gold. Ellipsometry and contact angle measurements indicate that analogous surfaces can be produced from 1,2-bis(11-mercaptoundecanoyl)-sn-glycero-3-phosphocholine and 1,2-bis[12-(isolipoyloxy)dodecanolyl]-sn-glycero-3- phosphocholine. The potential for adjusting and utilizing this new class of 'biomembrane-like' surfaces for biochemistry, biology, and medicine is briefly discused.

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