Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum
摘要：
Nitric oxide, which mediates influences of numerous neurotransmitters and modulators on vascular smooth muscle and leukocytes, can be formed in the brain from arginine by an enzymatic activity that stoichiometrically generates citrulline. We show that glutamate and related amino acids, such as N-methyl-D-aspartate, markedly stimulate arginine-citrulline transformation in cerebellar slices stoichiometrically with enhancement of cGMP levels. Nω-monomethyl-L-arginine blocks the augmentation both of citrulline and cGMP with identical potencies. Arginine competitively reverses both effects of Nω-monomethyl-L-arginine with the same potencies. Hemoglobin, which complexes nitric oxide, prevents the stimulation by N-methyl-D-aspartate of cGMP levels, and superoxide dismutase, which elevates nitric oxide levels, increases cGMP formation. These data establish that nitric oxide mediates the stimulation by glutamate of cGMP formation.
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关键词：
Neurobiology N-methyl-D-aspartate Arginine Citrulline Climbing Fibers Inositol Phospholipid Cycle
DOI：
10.1073/pnas.86.22.9030
被引量：
Taylor & Francis
Wiley
Semantic Scholar
万方医学
掌桥科研
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