A mutant immunoglobulin light chain is formed by aberrant DNA- and RNA-splicing events
摘要：
A mutant immunoglobulin gene has been formed by an abnormal (non V/J) recombination event such that abnormal RNA splicing is required to form a mutant light chain. The structure of the gene suggests that the small palindrome thought to be involved in V/J joining also provides the basis for this abnormal DNA recombination and that the absence of a J segment and RNA splice signal allows an abnormal RNA splicing reaction to occur.
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关键词：
Animals Mice Immunoglobulin Variable Region DNA RNA, Heterogeneous Nuclear Base Sequence Transcription, Genetic Recombination, Genetic Alleles Myeloma Proteins
DOI：
10.1038/286779a0
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