Direct Catalytic Asymmetric Aldol Reactions of Aldehydes with Unmodified Ketones
摘要:
Up to 94%ee can be achieved in the title reaction [Eq. (a)], which was previously only possible with enzymes. In this reaction LaLi3 tris(binaphthoxide) (LLB) imitates the function of enzymes by displaying both Lewis acidity and Brønsted basicity.
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DOI:
10.1002/anie.199718711
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年份:
1997
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