Candida-activated microbicidal mechanisms of human neutrophils and monocytes.

Damage to Candida albicans was determined by assays of leukocyte-induced inhibition of uptake of radioisotopes by hyphae. Neutrophils from 27 normal subjec...

RD Diamond，HVD Bossche

Candida-activated microbicidal mechanisms of human neutrophils and monocytes.

Damage to Candida albicans was determined by assays of leukocyte-induced inhibition of uptake of radioisotopes by hyphae. Neutrophils from 27 normal subjec...

R Diamond

NOX enzymes and the biology of reactive oxygen.

s generate high levels of reactive oxygen species (ROS) using a superoxide-generating NADPH oxidase as part of their armoury of microbicidal mechanisms. ...

Lambeth，J David - 《Nature Reviews Immunology》

Advances in antimicrobial peptide immunobiology.

Antimicrobial peptides are ancient components of the innate immune system and have been isolated from organisms spanning the phylogenetic spectrum. Over an...

NY Yount，AS Bayer，QX Yan，... - 《Peptide Science》

Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations.

We tested the in vitro susceptibility of Candida albicans to three defensins from human neutrophilic granulocytes (HNP-1, 2, and 3), a homologous defensin ...

RI Lehrer，T Ganz，D Szklarek，... - 《Journal of Clinical Investigation》

Phagolysosomal pH of human neutrophils.

6.35 +/- 0.35 after 30 min, and 5.68 +/- 0.26 after 60 min. The implications of these findings for neutrophil microbicidal mechanisms are discussed....

P Cech，RI Lehrer - 《Blood》

Coxiella burnetii: the ‘query’ fever bacterium : A model of immune subversion by a strictly intracellular microorganism

burnetii, a strictly intracellular pathogen, use to divert microbicidal mechanisms of macrophages and to depress protective T-cell mediated immunity. The role...

JL Mege，M Maurin，C Capo，... - 《Fems Microbiology Reviews》

Inducible nitric oxide synthase and nitric oxide production in Leishmania infantum -infected human macrophages stimulated with interferon-γ and bacterial ...

Nitric oxide produced by an inducible nitric oxide synthase constitutes one of the main microbicidal mechanisms of murine macrophages and its importance is...

MA Panaro，A Acquafredda，S Lisi，... - 《International Journal of Clinical & Laboratory Research》