Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture
摘要：
Manipulation or non-physiological embryo culture environments can lead to defective fetal programming in livestock. Our demonstration of reduced fetal methylation and expression of ovine IGF2R suggests pre-implantation embryo procedures may be vulnerable to epigenetic alterations in imprinted genes. This highlights the potential benefits of epigenetic diagnostic screening in developing embryo procedures.
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关键词：
Blastocyst Animals Sheep Abnormalities, Multiple Receptor, IGF Type 2 Genetic Screening Cloning, Organism DNA Methylation Genomic Imprinting Embryonic and Fetal Development
DOI：
10.1038/84769
被引量：
年份：
2001
Springer
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万方医学
掌桥科研
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