Fatal lymphomatoid granulomatosis with primary CNS-involvement in an immunocompetent 80-year-old woman
摘要：
An 80-year-old woman presented with weight loss, fatigue, dizziness and a brain stem lesion. Extensive work-up revealed () with primary clinical manifestation in the central nervous system (), a rare -driven multisystem , to be causative for the symptoms. Immunochemotherapy consisting of rituximab and temozolomide was started, but the disease progressed and the patient subsequently died. Histology, diagnostic criteria, differential diagnosis and treatment options for with involvement are discussed. This case demonstrates that with involvement may necessitate more aggressive treatment approaches than combination therapy with rituximab and temozolomide.
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DOI：
10.1136/bcr-2014-206825
被引量：
年份：
2014
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