Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
摘要：
Transfection of embryo fibroblasts by a human ras oncogene does not convert them into tumour cells unless the fibroblasts are established and immortalized before transfection. The embryo fibroblasts become tumorigenic if a second oncogene such as a viral or cellular myc gene or the gene for the polyoma large-T antigen is introduced together with the ras gene.
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关键词：
Animals Mice Fibroblasts Polyomavirus Cells, Cultured Cell Line Cell Transformation, Viral Antigens, Viral, Tumor Antigens, Viral Genetic Complementation Test
DOI：
10.1038/304596a0
被引量：
年份：
1983
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