Effect of acute and chronic anticonvulsant administration on endogenous gamma-hydroxybutyrate in rat brain.

阅读量:

60

作者:

OCS IiiLJ BeardenV Pegram

展开

摘要:

The effect of acute and chronic administration of ethosuximide, trimethadione, sodium valproate, clonazepam, phenobarbital, and diazepam on brain concentrations of γ-hydroxybutyrate (GHB) was determined by gas-liquid chromatography. The dose and time to sacrifice for each drug was determined by testing for effectiveness against GHB-induced absence seizures in the rat using an automated frequency analysis for quantitation of the electrocorticogram. Acute administration of ethosuximide, trimethadione, and sodium valproate, produced an increase in whole brain GHB. Ethosuximide, trimethadione, and phenobarbital given chronically produced a decrease in whole brain GHB. All changes took place in subcortex and cerebellum. Acute ethosuximide treatment produced a greater increase in GHB concentration at higher doses. The acute changes with the drugs coincided with the onset of anticonvulsant effect, but were short-lived and, in the case of ethosuximide and trimethadione, followed by a significant depression in GHB concentrations. The anti-petit mal action of these anticon-vulsants may be related to their effect on GHB in brain.

展开

DOI:

10.1016/0028-3908(80)90165-3

被引量:

222

年份:

1980

通过文献互助平台发起求助,成功后即可免费获取论文全文。

我们已与文献出版商建立了直接购买合作。

你可以通过身份认证进行实名认证,认证成功后本次下载的费用将由您所在的图书馆支付

您可以直接购买此文献,1~5分钟即可下载全文,部分资源由于网络原因可能需要更长时间,请您耐心等待哦~

身份认证 全文购买

相似文献

参考文献

引证文献

来源期刊

引用走势

1992
被引量:21

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用!

引用