Molecular genetics of regulated secretion in Paramecium
摘要：
Paramecium is a unicell in which cellular processes are amenable to genetic dissection. Regulated secretion, which designates a secretory pathway where secretory products are first stored in intracellular granules and then released by exocytotic membrane fusion upon external trigger, is an important function in Paramecium, involved in defensive response through the release of organelles called trichocysts. In this review, we focus on recent advances in the molecular genetics of two major aspects of the regulated pathway in Paramecium, the biogenesis of the secretory organelles and their exocytosis.
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关键词：
AED, aminoethyldextran DCV, dense core vesicle ER, endoplasmic reticulum GRL, granule lattice protein IG, immature granule kDa, kilo Dalton ND, non discharge NSF, N-ethylmaleimide-sensitive factor SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis SERCA, sarco(endo)plasmic reticulum-like calcium ATPase
DOI：
10.1016/S0300-9084(00)00201-7
被引量：
年份：
2000
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