Asymmetric aldol reaction of acetaldehyde and isatin derivatives for the total syntheses of ent-convolutamydine E and CPC-1 and a half fragment of madindoline A and B.
摘要：
The asymmetric aldol reaction of isatin derivatives and acetaldehyde has been developed using 4-hydroxydiarylprolinol as a catalyst, affording the aldol products with high enantioselectivity, these products being key intermediates in the synthesis of 3-hydroxyindole alkaloids. Short syntheses of ent-convolutamydine E and CPC-1 and a half fragment of madindoline A and B have been accomplished.
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关键词：
Biocatalytic racemization alpha-Hydroxycarboxylic acids Stereo-complementary alpha-hydroxyisocaproate dehydrogenases Lactobacillus spp
DOI：
10.1021/ol901432a
被引量：
年份：
2009
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