摘要：

This volume is dedicated lo the somatic hypermutation of immunoglobulin (Ig) genes. There has been considerable progress in the past few years in our understanding of the molecular mechanism of this process, the cellular events, and the diseases in which somatic hypermutation seems to play a major role. Most of the major issues are discussed in the chapters of this book or alluded to in this Introduction, and future challenges are outlined. Many mysteries remain on all the issues.

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