Methods of Binding of Cross-Beta Structures By Chaperones
The invention relates to the field of biochemistry, biophysical chemistry, molecular biology, structural biology, immunology, cellular biology and medicine. More in particular, the invention relates to the capability (or property) of cha...
MFBG Gebbink，B Bouma - US
Increasing genomic instability during premalignant neoplastic progression revealed through high resolution array-CGH
Chromosomal instability is regarded as an underlying mechanism of neoplastic progression, integral to the clonal selection and evolution that leads to canc...
LA Lai，TG Paulson，X Li，... - 《Genes Chromosomes & Cancer》
POSH INTERACTING PROTEINS AND RELATED METHODS
The application provides novel complexes of POSH polypeptides and POSH-associated proteins. The application also provides methods and compositions for treating POSH-associated diseases such as viral disorders, cancer, and neurological di...
DN Taglicht，I Alroy，Y Reiss，... - US
Highly concentrated stable meloxicam solutions for needleless injection
An aqueous cyclodextrin-free solution of meloxicam suitable is provided for administration by needleless injection, containing a pharmacologically acceptable meloxicam salt of an organic or inorganic base and one or more suitable excipie...
MA Folger，S Henke，B Hassel，... - WO
CASPASE 10 AS TARGET FOR MONITORING AND TREATMENT OF DISEASES
The present invention relates to a method of monitoring and/or modulating disease-associated activatory procceses which are mediated by caspase-10 or caspase-10 isoforms.
WALCZAK Henning，SPRICK Martin - EP
MODULAR NANOPARTICLES FOR ADAPTABLE VACCINES
Modular nanoparticle vaccine compositions and methods of making and using the same have been developed. Modular nanoparticle vaccine compositions comprise an antigen encapsulated in a polymeric particle and adaptor elements which modular...
IS Mellman，TM Fahmy，WM Saltzman，... - WO
HCV NS-3 Serine protease inhibitors
Peptidomimetic compounds are described which inhibit the NS3 protease of the hepatitis C virus (HCV). The compounds have the formula where the variable definitions are as provided in the specification. The compounds comprise a carbocycli...
A Rosenquist，F Thorstensson，PO Johansson，... - CA
Combination therapeutic compositions and method of use
The present invention provides pharmaceutical compositions and methods for the treatment of diabetes mellitus using combination therapy. The compositions r...
JC Jaen，JL Chen
Promotion of Epithelial Regeneration
The invention relates to the use of TGF-β3, or agents having TGF-β3 activity, to promote epithelial regeneration. Methods of manufacturing medicaments, and methods of promoting epithelial regeneration are both provided. In particular, ...
M Ferguson，S O'Kane，H Laverty，... - US
Gyrase inhibitors and uses thereof
The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compou...
P Charifson，D Deininger，AL Grillot，...
