摘要：

Presents research which identified the early-endosomal autoantigen EEA1 which binds the PI(3)K product phosphatidylinositol-3-phosphate in endosome fusion. Regulation of membrane traffic by GTPases and lipid kinases; Requirements for fusion between early endosomes; Association of EEA1 with the endosomal membrane; Identification of EEA1 as a direct Rab5 effector; Role of EEA1 in Rab5-dependent endocytic transport.

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