Genetic analysis of life-span in Caenorhabditis elegans
摘要：
Crosses between Bristol and Bergerac strains of the self-fertilizing hermaphroditic nematode Caenorhabditis elegans do not show the heterosis effects for life-span that complicate analysis of interstrain crosses with Drosophila or mice. Instead they yield F1progeny with life-spans similar to those of the parent strains. By analysis of life-span variation among progeny F2populations from such crosses and by two independent analyses of lifespans among recombinant inbred lines derived from F2individuals by 18 rounds of self-fertilization, we estimate that the heritability of life-span in C. elegans is between 20% and 50%. Recombinant inbred lines show a range in mean life-spans of 10 days to 31 days compared to life-spans of about 18 days for each of the two parental strains. We conclude that life-span variation in C. elegans has a substantial genetic component and that this organism offers promising opportunities for selective breeding of longer-lived strains and genetic analysis of senescence.
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DOI：
10.1073/pnas.79.21.6603
被引量：
年份：
1982
万方医学
Semantic Scholar
掌桥科研
Semantic Scholar
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dx.doi.org
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Oxford Univ Press
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The National Academy of Sciences of the United States of America
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Semantic Scholar
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NCBI
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Europe PMC
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The National Academy of Sciences of the United States of America
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