Peripheral H1-Blockade Effect of Fexofenadine

阅读量:

35

作者:

FER SimonsKJ Simons

展开

摘要:

Studies of the suppressive effect of H1-receptor antagonists on the histamine-induced wheal and flare are useful for assessing peripheral H1-blockade.To compare the peripheral H1-blockade produced by fexofenadine, 60 mg twice daily or 120 mg once daily; loratadine, 10 mg once daily; and placebo during 24 hours.In this randomized, double-blind, single-dose, crossover study in 20 subjects, the wheals and flares produced by epicutaneous tests with histamine phosphate 1 mg/mL were measured before and at intervals (20, 40, 60 minutes, hourly until 12 hours, and 24 hours) after the ingestion of fexofenadine, 60 mg twice daily; fexofenadine, 120 mg once daily; loratadine, 10 mg once daily; or placebo.All active medications effectively suppressed the histamine-induced wheal and flare for 24 hours compared with placebo. Fexofenadine 60 mg twice daily and fexofenadine 120 mg once daily had a faster onset of action than loratadine in this experimental model.Peripheral H1-blockade studies are useful for investigation of the differences among H1-receptor antagonists. They complement large clinical trials in which efficacy is subjectively assessed using symptom scores, and which are more likely to demonstrate similarities among the different medications in this class, and among different doses of the same H1-receptor antagonist.

展开

DOI:

10.1016/S1081-1206(10)63061-X

被引量:

207

年份:

1997

通过文献互助平台发起求助,成功后即可免费获取论文全文。

我们已与文献出版商建立了直接购买合作。

你可以通过身份认证进行实名认证,认证成功后本次下载的费用将由您所在的图书馆支付

您可以直接购买此文献,1~5分钟即可下载全文,部分资源由于网络原因可能需要更长时间,请您耐心等待哦~

身份认证 全文购买

相似文献

参考文献

引证文献

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用!

关于我们

百度学术集成海量学术资源,融合人工智能、深度学习、大数据分析等技术,为科研工作者提供全面快捷的学术服务。在这里我们保持学习的态度,不忘初心,砥砺前行。
了解更多>>

友情链接

百度云百度翻译

联系我们

合作与服务

期刊合作 图书馆合作 下载产品手册

©2025 Baidu 百度学术声明 使用百度前必读

引用