摘要：

4-(Methylthio)acetophenone is an important drug intermediate used for the synthesis of Vioxx (Rofecoxib), an NSAID, which has selective COX-2 inhibition. It is typically produced on industrial scale by Friedel–Crafts acylation using homogeneous corrosive and polluting acid catalysts such as aluminium chloride in more than stoichiometric amounts with acetyl chloride as the acylating agent. This...

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