Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III.
摘要:
Presents the results of a functional genomic screen to identify genes required for cell division in Caenorhabditis elegans. Inhibition of the expression of predicted open reading frames on chromosome III using RNA-mediated interference (RNAi); Identification of 133 genes necessary for distinct cellular processes in early embryos; Indication that these genes represent most of the genes on chromosome III that are required for proper cell division in embryos; Usefulness of the screen for providing putative gene functions for other species.
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年份:
2000
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