Use of fluorescence spectroscopy to study conformational changes in the β2-adrenoceptor - ScienceDirect
摘要：
In the present study we show that two-dimensional (2-D) maps together with immunodetection allow the precise identification of important leukocyte differentiation and tumor markers (e.g., CD3 and CD5), and important cell cycle regulatory molecules such as cyclin dependent kinases, notably CDK6. In addition, the comparative evaluation of molecular expression (e.g., CD5) in maps developed with normal and lymphoma samples can provide reproducible and precise information regarding the molecular expression in different cell populations. Accordingly, we could detect a much increased level of expression of CD5 in mantle cell lymphoma, up to ten times higher than in the control. In addition, CD5 in tumor tissues seems to be microheterogeneous as compared to normal samples.
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关键词：
Rhodopsin Receptors, Adrenergic, beta-2 Fluorescent Dyes Chromatography, Liquid Spectrometry, Fluorescence Amino Acid Sequence Protein Conformation Molecular Sequence Data
DOI：
10.1016/S0076-6879(02)43134-5
被引量：
年份：
2002
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