Chromosome Replication and the Division Cycle of Escherichia coli B/r
摘要：
It is suggested that the replication of the bacterial genome during the division cycle of Escherichia coli B r growing with doubling times between approximately 20 and 60 minutes can be described by two constants: C, the time for a replication point to traverse the genome, and D, the time between the end of a round of replication and cell division. Direct measurements of C, D and C + D agree with the model. The predictions of the model are consistent with autoradiographic and biochemical data, and with the finding of "gaps" in DNA synthesis during slow growth and multiple replication forks during rapid growth. Measurements of the DNA content of cells with predicted chromosome configurations led to an estimate of the molecular weight of the bacterial genome (non-replicating) of 2.6 × 10 9 daltons, in good agreement with other, independent measurements.
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关键词：
Chromosomes, Bacterial Cell Nucleus Escherichia coli DNA, Bacterial Autoradiography Kinetics Cell Division DNA Replication Models, Biological Time Factors
DOI：
10.1016/0022-2836(68)90425-7
被引量：
年份：
1968
Elsevier
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万方医学
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