Sustained release hormonal preparations
摘要：
Mean diffusion of 6-methyl-16-methylene-17α-acetoxypregna-4, 6-diene-3, 20-dione through dimethylpolysiloxane membrane into water was 140 μg/24 hrs/100 mm2/0.1 mm; (dl)-13β-ethyl-17α-ethynyl-17β-hydroxygon-4-en-3-one diffused with a rate of 73 μg/24 hrs/100 mm2/0.1 mm. When plasma instead of water was used for incubation, the diffusion rates were increased by the following factors: 2.4 times for 19-norpregn-4-ene-3, 20-dione; 1.5 times for 6-methyl-17α-acetoxypregna-4, 6-diene-3, 20-dione, and 4.7 times for (dl)-13β-ethyl-17α-ethynyl-17β-hydroxygon-4-en-3-one. Measurements of diffusion through porous glass discs, and of solubility in different solvents indicated that the steroid molecules diffuse through the dimethylpolysiloxane in a non-solvated form.
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关键词：
Contraceptive Implants Megestrol Acetate Cytologic Effects Steroid Metabolic Effects Hematological Effects Lipid Metabolic Effects Hormone Receptors Contraceptive Use-Effectiveness Literature Review Side Effects
DOI：
10.1016/S0039-128X(68)80115-1
被引量：
年份：
1968
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