A Diarylprolinol in an Asymmetric, Catalytic, and Direct Crossed‐Aldol Reaction of Acetaldehyde
摘要：
No over‐reacting: A diarylprolinol was found to be an effective organocatalyst of the direct, enantioselective aldol reaction of acetaldehyde, affording β‐hydroxy α‐unsubstituted aldehydes in good yield with excellent enantioselectivity (see scheme). In the proposed transition state the aldehyde reacts on the more hindered face of the intermediate enamine as a consequence of the hydrogen bond between the aldehyde and the OH group of the organocatalyst.
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DOI：
10.1002/anie.200704870
被引量：
年份：
2007
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