Discovery of Potent Cell Migration Inhibitors through Total Synthesis: Lessons from StructureActivity Studies of (+)-Migrastatin
摘要：
Synthesis of highly active migrastatin-based tumor migration cell inhibitors has been accomplished. Our flexible and concise total synthesis of migrastatin has allowed us to explore otherwise inaccessible migrastatin-derived structural motifs. This effort has resulted in the discovery of analogues with tumor cell migration inhibitory activity 3 orders of magnitude higher than that of the natural product.
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关键词：
Discovery of Potent Cell Migration Inhibitors through Total Synthesis Lessons from Structure-Activity Studies of (+)-Migrastatin, Artículo
DOI：
10.1021/ja039714a
被引量：
年份：
2004
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