Endoplasmic reticulum stress, obesity and diabetes

来自掌桥科研

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阅读量：

216

作者：

M Cnop，F Foufelle，LA Velloso

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摘要：

The endoplasmic reticulum (ER) stress response, also commonly known as the unfolded protein response (UPR), is an adaptive response used to align ER functional capacity with demand. It is activated in various tissues under conditions related to obesity and type 2 diabetes. Hypothalamic ER stress contributes to inflammation and leptin/insulin resistance. Hepatic ER stress contributes to the development of steatosis and insulin resistance, and components of the UPR regulate liver lipid metabolism. ER stress in enlarged fat tissues induces inflammation and modifies adipokine secretion, and saturated fats cause ER stress in muscle. Finally, prolonged ER stress impairs insulin synthesis and causes pancreatic β cell apoptosis. In this review, we discuss ways in which ER stress operates as a common molecular pathway in the pathogenesis of obesity and diabetes.

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关键词：

Animals Humans Diabetes Mellitus Obesity Signal Transduction Endoplasmic Reticulum Stress

DOI：

10.1016/j.molmed.2011.07.010

被引量：

618

年份：

2012