Signaling Switch of the Axon Guidance Receptor Robo3 during Vertebrate Evolution
摘要：
Axon guidance mechanisms at the midline are thought to be highly conserved in evolution. However, Zelina etal. show here that mammalian Robo3 receptors have unique signaling properties and function. They do not bind Slits and mediate Netrin-1 attraction. This might have contributed to the emergence of mammalian-specific commissural circuits.
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关键词：
Axons Animals Zebrafish Humans Mice src-Family Kinases Glycoproteins Nerve Growth Factors Membrane Proteins Receptors, Cell Surface
DOI：
10.1016/j.neuron.2014.11.004
被引量：
年份：
2014
Elsevier
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