The role of NF│蔅 in lymphoid malignancies
摘要：
Nuclear Factor kappaB (NF-κB) transcription factors are central regulators of lymphocyte proliferation, survival and development. Although normally subject to tight control, constitutive activation of NF-κB promotes inappropriate lymphocyte survival and proliferation, and is recognised as key pathological feature in various lymphoid malignancies. Inhibition of NF-κB may be an attractive therapeutic approach in these diseases. This review focuses on the mechanisms and functional consequences of NF-κB activation in lymphoid malignancies and potential therapeutic strategies for inhibition of NF-κB.
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DOI：
10.1111/j.1365-2141.2008.07284.x
被引量：
年份：
2010
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