摘要：

La is a conserved RNA-binding phosphoprotein that inter- acts with a large variety of ligands. The most ubiquitous func- tion of La is association with newly synthesized RNA polymer- ase (Pol) III transcripts via their common UUU-OH 39 termini and stabilization of these against exonucleolytic digestion. Ac- cumulating evidence also indicates an activity for La in internal ribosome entry site-mediated translation in mammalian cells and in the metabolism of a subset of 39-processed snRNA intermediates that end in uridylates but are synthesized by Pol II. The most highly conserved region of La resides in the N-terminal domain (NTD), and this appears to mediate high- affinity UUU-OH recognition. As critically reviewed here by comparison to a consensus core RNA recognition motif

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