2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
申请(专利)号:
US 09/554,162
申请日期:
Oct 31, 1998
公开/公告号:
US 6362178 B1
公开/公告日期:
Mar 26, 2002
申请(专利权)人:
Bayer Schering Pharma Aktiengesellschaft (Berlin, DE)
被引量:
摘要:
The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
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