2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors

阅读量:

36

申请(专利)号:

US 09/554,162

申请日期:

Oct 31, 1998

公开/公告号:

US 6362178 B1

公开/公告日期:

Mar 26, 2002

申请(专利权)人:

Bayer Schering Pharma Aktiengesellschaft (Berlin, DE)

被引量:

289

摘要:

The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.

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