Insulin-like growth factor I, growth hormone and insulin in white adipose tissue
摘要：
Both growth hormone (GH) and insulin-like growth factor I (IGF-I) are of major significance in adipocyte differentiation. IGF-I has been suggested to be a major regulator of cell proliferation, differentiation and metabolism, thus regulating, among other biological processes, adipose tissue growth and differentiation of pre-adipocytes into adipocytes. GH exerts its effects by increasing the pool of adipocyte precursor cells capable of differentiating into mature adipocytes. In addition, GH seems to have the potential to reduce the volume of mature adipocytes, thus inhibiting the expansion of adipose tissue and reducing body fat.This chapter gives an overview of studies that have investigated the roles of insulin, GH and IGF-I in adipogenesis.
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关键词：
adipocyte differentiation pre-adipocytes adipocyte precursor cells GH IGF-I insulin white adipose tissue
DOI：
10.1016/j.beem.2005.07.011
被引量：
年份：
2005
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