HMGA2 regulates the in vitro aging and proliferation of human umbilical cord blood-derived stromal cells through the mTOR/p70S6K signaling pathway.
摘要：
HMGA2 is an architectural transcription factor that alters chromatin structure. HMGA2 induced a PI3K/AKT/mTOR/p70S6K cascade. Overexpression of HMGA2 activated cell cycle related genes. Overexpression of HMGA2 inhibited CDK inhibitors. Overexpression of HMGA2 enhances proliferation and reduces the SA-β-gal activity.
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关键词：
Humans Stromal Cells Fetal Blood beta-Galactosidase Ribosomal Protein S6 Kinases, 70-kDa HMGA2 Protein Cell Cycle Proteins Oligonucleotide Array Sequence Analysis Cell Aging Signal Transduction
DOI：
10.1016/j.scr.2012.11.002
被引量：
年份：
2012
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