Extreme sensitivity to ultraviolet light in the fungal pathogen causing white-nose syndrome of bats

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105

作者：

JM Palmer，KP Drees，JT Foster，DL Lindner

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摘要：

Bat white-nose syndrome (WNS), caused by the fungal pathogenPseudogymnoascus destructans, has decimated North American hibernating bats since its emergence in 2006. Here, we utilize comparative genomics to examine the evolutionary history of this pathogen in comparison to six closely related nonpathogenic species.P. destructansdisplays a large reduction in carbohydrate-utilizing enzymes (CAZymes) and in the predicted secretome (~50%), and an increase in lineage-specific genes. The pathogen has lost a key enzyme, UVE1, in the alternate excision repair (AER) pathway, which is known to contribute to repair of DNA lesions induced by ultraviolet (UV) light. Consistent with a nonfunctional AER pathway,P. destructansis extremely sensitive to UV light, as well as the DNA alkylating agent methyl methanesulfonate (MMS). The differential susceptibility ofP. destructansto UV light in comparison to other hibernacula-inhabiting fungi represents a potential "Achilles' heel" ofP. destructansthat might be exploited for treatment of bats with WNS. White-nose syndrome, caused by the fungusPseudogymnoascus destructans, is decimating North American bats. Here, Palmer et al. use comparative genomics to examine the evolutionary history of this pathogen, and show that it has lost a crucial DNA repair enzyme and is extremely sensitive to UV light.

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关键词：

WHITE-nose syndrome PATHOGENIC fungi ULTRAVIOLET radiation PSEUDOGYMNOASCUS destructans GENOMICS

DOI：

10.1038/s41467-017-02441-z

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年份：

2018