摘要：

Transdermal drug delivery generated major interest among large pharmaceutical companies in the 1980s and 1990s due to potential advantages of avoidance of first-pass metabolism, avoidance of exposure to the chemical and biological conditions of the gastrointestinal tract, reduction or avoidance of adverse events, improved patient compliance. Ethosome delivery system was established to develop a patented, passive, non-invasive, transdermal drug delivery technology they are interesting and pioneering vesicular systems that have appeared in the field of pharmaceutical technology and drug delivery in recent years. This carrier presents interesting features correlated with its ability to permeate intact through the human skin due to its high deformability. Ethosomes are soft, malleable vesicles tailored for enhanced delivery of active agents. It has been shown that the physicochemical characteristics of ethosomes allow this vesicular carrier to transport active substances more efficaciously through the stratum corneum into the deeper layers of the skin than conventional liposomes. This aspect is of great importance for the design of carriers to be applied topically both for topical and systemic drug administration. KEYWORDS: Ethosome, Transdermal drug delivery, Vesicle, Topical delivery

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