Noninvasive Imaging of Quantum Dots in Mice
摘要：
Quantum dots having four different surface coatings were tested for use in in vivo imaging. Localization was successfully monitored by fluorescence imaging of living animals, by necropsy, by frozen tissue sections for optical microscopy, and by electron microscopy, on scales ranging from centimeters to nanometers, using only quantum dots for detection. Circulating half-lives were found to be less than 12 min for amphiphilic poly(acrylic acid), short-chain (750 Da) methoxy-PEG or long-chain (3400 Da) carboxy-PEG quantum dots, but approximately 70 min for long-chain (5000 Da) methoxy-PEG quantum dots. Surface coatings also determined the in vivo localization of the quantum dots. Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo.
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关键词：
Animals Mice, Inbred BALB C Mice Spleen Polyethylene Glycols Fluorescent Dyes Diagnostic Imaging Microscopy, Electron Microscopy, Fluorescence Image Processing, Computer-Assisted
DOI：
10.1021/bc034153y
被引量：
年份：
2004
Taylor & Francis
ACS
dx.doi.org
NCBI
Oxford Univ Press
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