Toll-like Receptor Signaling
阅读量：
448
摘要：
One of the mechanisms by which the innate immune system senses the invasion of pathogenic microorganisms is through the Toll-like receptors (TLRs), which recognize specific molecular patterns that are present in microbial components. Stimulation of different TLRs induces distinct patterns of gene expression, which not only leads to the activation of innate immunity but also instructs the development of antigen-specific acquired immunity. Here, we review the rapid progress that has recently improved our understanding of the molecular mechanisms that mediate TLR signalling.
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关键词：
Animals Mice, Knockout Humans Mice Macromolecular Substances Adaptor Proteins, Signal Transducing Membrane Glycoproteins Receptors, Cell Surface Receptors, Immunologic Receptors, Interleukin-1
DOI：
10.1074/jbc.R300028200
被引量：
年份：
2003
Elsevier
Taylor & Francis
doi.org
万方医学
NCBI
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