Asymmetric reduction carbonyl compounds to chiral alcohols by baker's yeast

来自 知网

阅读量:

32

作者:

H HuangZH YangSJ Yao

展开

摘要:

Optically active alcohols are the most important chiral intermediates in synthesis single enantiomeric pharmaceuticals. The asymmetric reduction of methyl aliphatic ketone and β oxo ester to corresponding chiral alcohols by baker's yeast in aqueous was investigated when 2 octanone and ethyl 4 chloro 3 oxobutanoate (COBE) were taken as the model substrates respectively . The experimental results indicated the reduction product was mainly S 2 octanol when 2 octanone was reduced. The stereoselectivity was excellence. When the COBE was reduced, the product was mainly S configuration. The results indicated that both the conversion and the stereoselectivity of reaction were attractive for asymmetric reduction. And it was found that the concentration of COBE and product had some degree negative effect on the asymmetric reduction.

展开

被引量:

9

年份:

2004

通过文献互助平台发起求助,成功后即可免费获取论文全文。

相似文献

参考文献

引证文献

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用!

关于我们

百度学术集成海量学术资源,融合人工智能、深度学习、大数据分析等技术,为科研工作者提供全面快捷的学术服务。在这里我们保持学习的态度,不忘初心,砥砺前行。
了解更多>>

友情链接

百度云百度翻译

联系我们

合作与服务

期刊合作 图书馆合作 下载产品手册

©2025 Baidu 百度学术声明 使用百度前必读

引用