摘要：

Optically active alcohols are the most important chiral intermediates in synthesis single enantiomeric pharmaceuticals. The asymmetric reduction of methyl aliphatic ketone and β oxo ester to corresponding chiral alcohols by baker's yeast in aqueous was investigated when 2 octanone and ethyl 4 chloro 3 oxobutanoate (COBE) were taken as the model substrates respectively . The experimental results indicated the reduction product was mainly S 2 octanol when 2 octanone was reduced. The stereoselectivity was excellence. When the COBE was reduced, the product was mainly S configuration. The results indicated that both the conversion and the stereoselectivity of reaction were attractive for asymmetric reduction. And it was found that the concentration of COBE and product had some degree negative effect on the asymmetric reduction.

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